BMP7
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- SMAD protein signal transduction [IDA]
- cellular response to hypoxia [ISS]
- dendrite development [TAS]
- epithelial to mesenchymal transition [TAS]
- extracellular matrix organization [TAS]
- mesenchymal cell differentiation [IDA]
- mesenchyme development [ISS]
- mesonephros development [IEP]
- metanephros development [IEP]
- monocyte aggregation [IDA]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of NF-kappaB import into nucleus [ISS]
- negative regulation of NF-kappaB transcription factor activity [ISS]
- negative regulation of cell cycle [IDA]
- negative regulation of cell death [IDA]
- negative regulation of glomerular mesangial cell proliferation [IDA]
- negative regulation of mitosis [IDA]
- negative regulation of neuron differentiation [IDA]
- negative regulation of phosphorylation [IDA]
- negative regulation of striated muscle cell apoptotic process [ISS]
- negative regulation of transcription, DNA-templated [IDA]
- neuron projection morphogenesis [IDA]
- positive regulation of bone mineralization [IDA]
- positive regulation of dendrite development [IDA]
- positive regulation of heterotypic cell-cell adhesion [IDA]
- positive regulation of hyaluranon cable assembly [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA, TAS]
- positive regulation of peptidyl-threonine phosphorylation [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein localization to nucleus [IDA]
- regulation of apoptotic process [IBA]
- regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- regulation of removal of superoxide radicals [ISS]
- skeletal system development [TAS]
- steroid hormone mediated signaling pathway [IMP]
- ureteric bud development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BMPR1B
Gene Ontology Biological Process
- BMP signaling pathway [IDA, NAS, TAS]
- cartilage condensation [NAS]
- eye development [ISS]
- limb morphogenesis [IMP]
- ovarian cumulus expansion [ISS]
- ovulation cycle [ISS]
- positive regulation of bone mineralization [IMP]
- positive regulation of cell differentiation [IMP]
- positive regulation of osteoblast differentiation [IMP]
- protein phosphorylation [IDA]
- skeletal system development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.
Bone morphogenetic proteins (BMPs) are multifunctional proteins, structurally related to transforming growth factor-beta (TGF-beta) and activin. TGF-beta and activin exert their effects by forming heteromeric complexes of type I and type II serine/threonine kinase receptors. We have previously identified a series of type I serine/threonine kinase receptors, termed activin receptor-like kinase (ALK)-1 to -6. ALK-5 is a TGF-beta type I ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BMP7 BMPR1B | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID