BAIT
CHMP4C
SNF7-3, Shax3, VPS32C
charged multivesicular body protein 4C
GO Process (10)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- abscission [IMP]
- cytokinesis checkpoint [IMP]
- endosomal transport [TAS]
- membrane organization [TAS]
- negative regulation of cytokinesis [IMP]
- positive regulation of viral release from host cell [IMP]
- regulation of viral process [IMP]
- ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [IMP]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RAP1A
C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21
RAP1A, member of RAS oncogene family
GO Process (20)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- Rap protein signal transduction [IMP]
- activation of MAPKK activity [TAS]
- blood coagulation [TAS]
- cellular response to cAMP [IDA]
- cellular response to nerve growth factor stimulus [ISS]
- energy reserve metabolic process [TAS]
- establishment of endothelial barrier [IMP]
- nerve growth factor signaling pathway [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of Rap GTPase activity [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of protein kinase activity [ISS]
- positive regulation of vasculogenesis [ISS]
- protein transport [IDA]
- regulation of cell junction assembly [IMP]
- regulation of insulin secretion [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis.
The midbody is an organelle assembled at the intercellular bridge between the two daughter cells at the end of mitosis. It controls the final separation of the daughter cells and has been involved in cell fate, polarity, tissue organization, and cilium and lumen formation. Here, we report the characterization of the intricate midbody protein-protein interaction network (interactome), which identifies many ... [more]
Unknown Dec. 04, 2018; 10(1);4513 [Pubmed: 31586073]
Throughput
- High Throughput
Curated By
- BioGRID