ADRB2
Gene Ontology Biological Process
- activation of adenylate cyclase activity [IDA]
- activation of transmembrane receptor protein tyrosine kinase activity [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- adrenergic receptor signaling pathway [IDA]
- cell surface receptor signaling pathway [TAS]
- desensitization of G-protein coupled receptor protein signaling pathway by arrestin [IDA]
- endosome to lysosome transport [TAS]
- positive regulation of MAPK cascade [IDA]
- positive regulation of protein ubiquitination [IMP]
- receptor-mediated endocytosis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CAV3
Gene Ontology Biological Process
- T-tubule organization [TAS]
- caveola assembly [IDA]
- cell differentiation [ISS]
- cell growth [ISS]
- cholesterol homeostasis [ISS]
- endocytosis [ISS]
- glucose homeostasis [ISS]
- membrane raft organization [ISS]
- muscle cell cellular homeostasis [ISS]
- muscle organ development [TAS]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of MAPK cascade [ISS]
- negative regulation of calcium ion transport [IDA]
- negative regulation of cardiac muscle hypertrophy [IMP]
- negative regulation of cell size [IMP]
- negative regulation of nitric-oxide synthase activity [ISS]
- negative regulation of potassium ion transmembrane transport [ISS]
- negative regulation of potassium ion transmembrane transporter activity [ISS]
- negative regulation of protein kinase activity [ISS]
- negative regulation of protein localization to cell surface [NAS]
- negative regulation of sarcomere organization [IMP]
- plasma membrane organization [ISS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of microtubule polymerization [ISS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [NAS]
- protein localization [ISS]
- protein localization to plasma membrane [ISS]
- regulation of calcium ion import [IDA]
- regulation of calcium ion transmembrane transporter activity [IDA]
- regulation of cardiac muscle contraction [IMP]
- regulation of heart contraction [ISS]
- regulation of heart rate [IMP]
- regulation of membrane depolarization during cardiac muscle cell action potential [IMP]
- regulation of membrane potential [IDA]
- regulation of nerve growth factor receptor activity [IMP]
- regulation of signal transduction by receptor internalization [IMP]
- regulation of skeletal muscle contraction [IMP]
- regulation of sodium ion transmembrane transporter activity [IDA]
- regulation of ventricular cardiac muscle cell membrane depolarization [IDA]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- triglyceride metabolic process [ISS]
- ventricular cardiac muscle cell action potential [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
G-protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global view of GPCR-mediated signaling and to identify novel components of their pathways, we used a modified membrane yeast two-hybrid (MYTH) ... [more]
Throughput
- High Throughput
Additional Notes
- interaction identified using a modified split-ubiquitin membrane yeast two-hybrid (MYTH) assay
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ADRB2 CAV3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID