PDGFA
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- actin cytoskeleton organization [ISS]
- angiogenesis [ISS]
- blood coagulation [TAS]
- cell activation [TAS]
- cell projection assembly [ISS]
- cell-cell signaling [TAS]
- embryonic lung development [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- hair follicle development [ISS]
- innate immune response [TAS]
- lung alveolus development [ISS]
- negative chemotaxis [IDA]
- negative regulation of phosphatidylinositol biosynthetic process [IDA]
- negative regulation of platelet activation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- organ morphogenesis [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- platelet-derived growth factor receptor signaling pathway [IDA]
- positive regulation of DNA replication [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein autophosphorylation [IDA]
- positive regulation of protein kinase B signaling [IDA]
- regulation of DNA biosynthetic process [IDA]
- regulation of actin cytoskeleton organization [TAS]
- regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling [ISS]
- regulation of glomerular mesangial cell proliferation [IDA]
- regulation of peptidyl-tyrosine phosphorylation [ISS]
- regulation of smooth muscle cell migration [IDA]
- response to wounding [IDA]
- skin development [ISS]
- wound healing [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PLCG1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- T cell receptor signaling pathway [TAS]
- activation of MAPKK activity [TAS]
- activation of phospholipase C activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- calcium-mediated signaling [IMP]
- cell migration [IMP]
- cellular response to epidermal growth factor stimulus [IDA, IMP]
- cytokine-mediated signaling pathway [TAS]
- epidermal growth factor receptor signaling pathway [IMP, TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- inositol phosphate metabolic process [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of angiogenesis [IDA]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of release of sequestered calcium ion into cytosol [IMP]
- signal transduction [NAS, TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1.
We have identified two tyrosine phosphorylation sites, Tyr 1009 and Tyr 1021, in the C-terminal noncatalytic region of the human platelet-derived growth factor (PDGF) receptor beta subunit. Mutant receptors with phenylalanine substitutions at either or both of these tyrosines were expressed in dog epithelial cells. Mutation of Tyr 1021 markedly reduced the PDGF-stimulated binding of phospholipase C (PLC) gamma 1 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID