BAIT
ADRB2
ADRB2R, ADRBR, B2AR, BAR, BETA2AR
adrenoceptor beta 2, surface
GO Process (10)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- activation of adenylate cyclase activity [IDA]
- activation of transmembrane receptor protein tyrosine kinase activity [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- adrenergic receptor signaling pathway [IDA]
- cell surface receptor signaling pathway [TAS]
- desensitization of G-protein coupled receptor protein signaling pathway by arrestin [IDA]
- endosome to lysosome transport [TAS]
- positive regulation of MAPK cascade [IDA]
- positive regulation of protein ubiquitination [IMP]
- receptor-mediated endocytosis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ABCA7
ABCA-SSN, ABCX
ATP-binding cassette, sub-family A (ABC1), member 7
GO Process (20)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- apolipoprotein A-I-mediated signaling pathway [IDA]
- cholesterol efflux [IDA]
- high-density lipoprotein particle assembly [IDA]
- memory [ISS]
- negative regulation of ATPase activity [IDA]
- negative regulation of amyloid precursor protein biosynthetic process [ISS]
- negative regulation of beta-amyloid formation [ISS]
- peptide cross-linking [ISS]
- phospholipid efflux [IDA]
- phospholipid scrambling [IDA]
- positive regulation of ATPase activity [IDA]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of beta-amyloid clearance [ISS]
- positive regulation of cholesterol efflux [ISS]
- positive regulation of engulfment of apoptotic cell [ISS]
- positive regulation of phagocytosis [ISS]
- positive regulation of phospholipid efflux [ISS]
- protein localization to nucleus [ISS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
G-protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global view of GPCR-mediated signaling and to identify novel components of their pathways, we used a modified membrane yeast two-hybrid (MYTH) ... [more]
Mol. Syst. Biol. Dec. 15, 2016; 13(3);918 [Pubmed: 28298427]
Throughput
- High Throughput
Additional Notes
- interaction identified using a modified split-ubiquitin membrane yeast two-hybrid (MYTH) assay
Curated By
- BioGRID