BAIT
CCR2
CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R, hCG_14621
chemokine (C-C motif) receptor 2
GO Process (33)
GO Function (3)
GO Component (9)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- T-helper 17 cell chemotaxis [ISS]
- blood vessel remodeling [ISS]
- cellular calcium ion homeostasis [ISS]
- cellular defense response [TAS]
- cellular homeostasis [ISS]
- chemokine-mediated signaling pathway [ISS]
- chemotaxis [TAS]
- cytokine-mediated signaling pathway [IDA]
- dendritic cell chemotaxis [TAS]
- immune response [TAS]
- innate immune response [TAS]
- negative regulation of adenylate cyclase activity [TAS]
- negative regulation of angiogenesis [ISS]
- negative regulation of eosinophil degranulation [ISS]
- negative regulation of type 2 immune response [ISS]
- positive regulation of CD8-positive, alpha-beta T cell extravasation [ISS]
- positive regulation of T cell activation [ISS]
- positive regulation of T cell chemotaxis [ISS]
- positive regulation of T-helper 1 type immune response [ISS]
- positive regulation of alpha-beta T cell proliferation [ISS]
- positive regulation of astrocyte chemotaxis [IDA]
- positive regulation of cytosolic calcium ion concentration [TAS]
- positive regulation of hematopoietic stem cell migration [ISS]
- positive regulation of immune complex clearance by monocytes and macrophages [ISS]
- positive regulation of inflammatory response [ISS]
- positive regulation of interferon-gamma production [ISS]
- positive regulation of interleukin-2 production [ISS]
- positive regulation of monocyte chemotaxis [IDA, ISS]
- positive regulation of monocyte extravasation [ISS]
- positive regulation of tumor necrosis factor biosynthetic process [ISS]
- regulation of vascular endothelial growth factor production [ISS]
- response to wounding [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
APP
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
amyloid beta (A4) precursor protein
GO Process (29)
GO Function (8)
GO Component (21)
Gene Ontology Biological Process
- adult locomotory behavior [ISS]
- axon cargo transport [ISS]
- axon midline choice point recognition [ISS]
- axonogenesis [ISS]
- blood coagulation [TAS]
- cellular copper ion homeostasis [ISS]
- collateral sprouting in absence of injury [ISS]
- dendrite development [ISS]
- endocytosis [ISS]
- extracellular matrix organization [ISS, TAS]
- innate immune response [TAS]
- ionotropic glutamate receptor signaling pathway [ISS]
- locomotory behavior [ISS]
- mRNA polyadenylation [ISS]
- mating behavior [ISS]
- negative regulation of endopeptidase activity [IDA]
- neuron apoptotic process [IMP]
- neuron projection development [ISS]
- neuron remodeling [ISS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of mitotic cell cycle [ISS]
- protein phosphorylation [ISS]
- regulation of epidermal growth factor-activated receptor activity [ISS]
- regulation of multicellular organism growth [ISS]
- regulation of synapse structure or activity [ISS]
- regulation of translation [ISS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISS]
- axon [ISS]
- cell surface [IDA]
- cytoplasm [IDA, ISS]
- cytosol [TAS]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- endosome [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of membrane [ISS]
- integral component of plasma membrane [TAS]
- intracellular membrane-bounded organelle [IDA]
- membrane raft [IDA]
- nuclear envelope lumen [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- platelet alpha granule lumen [TAS]
- receptor complex [IDA]
- synapse [IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
G-protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global view of GPCR-mediated signaling and to identify novel components of their pathways, we used a modified membrane yeast two-hybrid (MYTH) ... [more]
Mol. Syst. Biol. Dec. 15, 2016; 13(3);918 [Pubmed: 28298427]
Throughput
- High Throughput
Additional Notes
- interaction identified using a modified split-ubiquitin membrane yeast two-hybrid (MYTH) assay
Curated By
- BioGRID