BAIT
CCR2
CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R, hCG_14621
chemokine (C-C motif) receptor 2
GO Process (33)
GO Function (3)
GO Component (9)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- T-helper 17 cell chemotaxis [ISS]
- blood vessel remodeling [ISS]
- cellular calcium ion homeostasis [ISS]
- cellular defense response [TAS]
- cellular homeostasis [ISS]
- chemokine-mediated signaling pathway [ISS]
- chemotaxis [TAS]
- cytokine-mediated signaling pathway [IDA]
- dendritic cell chemotaxis [TAS]
- immune response [TAS]
- innate immune response [TAS]
- negative regulation of adenylate cyclase activity [TAS]
- negative regulation of angiogenesis [ISS]
- negative regulation of eosinophil degranulation [ISS]
- negative regulation of type 2 immune response [ISS]
- positive regulation of CD8-positive, alpha-beta T cell extravasation [ISS]
- positive regulation of T cell activation [ISS]
- positive regulation of T cell chemotaxis [ISS]
- positive regulation of T-helper 1 type immune response [ISS]
- positive regulation of alpha-beta T cell proliferation [ISS]
- positive regulation of astrocyte chemotaxis [IDA]
- positive regulation of cytosolic calcium ion concentration [TAS]
- positive regulation of hematopoietic stem cell migration [ISS]
- positive regulation of immune complex clearance by monocytes and macrophages [ISS]
- positive regulation of inflammatory response [ISS]
- positive regulation of interferon-gamma production [ISS]
- positive regulation of interleukin-2 production [ISS]
- positive regulation of monocyte chemotaxis [IDA, ISS]
- positive regulation of monocyte extravasation [ISS]
- positive regulation of tumor necrosis factor biosynthetic process [ISS]
- regulation of vascular endothelial growth factor production [ISS]
- response to wounding [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RHOG
ARHG
ras homolog family member G
GO Process (14)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- GTP catabolic process [IDA, TAS]
- Rac protein signal transduction [IDA]
- Rho protein signal transduction [IDA]
- actin cytoskeleton organization [IDA]
- activation of Rac GTPase activity [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell chemotaxis [IMP]
- platelet activation [TAS]
- positive regulation of cell proliferation [TAS]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
G-protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global view of GPCR-mediated signaling and to identify novel components of their pathways, we used a modified membrane yeast two-hybrid (MYTH) ... [more]
Mol. Syst. Biol. Dec. 15, 2016; 13(3);918 [Pubmed: 28298427]
Throughput
- High Throughput
Additional Notes
- interaction identified using a modified split-ubiquitin membrane yeast two-hybrid (MYTH) assay
Curated By
- BioGRID