BAIT
CCR8
CC-CKR-8, CCR-8, CDw198, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, TER1
chemokine (C-C motif) receptor 8
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
THY1
CD90
Thy-1 cell surface antigen
GO Process (13)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- T cell receptor signaling pathway [ISS]
- angiogenesis [ISS]
- cytoskeleton organization [ISS]
- focal adhesion assembly [ISS]
- negative regulation of T cell receptor signaling pathway [ISS]
- negative regulation of axonogenesis [ISS]
- negative regulation of cell migration [ISS]
- negative regulation of protein kinase activity [ISS]
- positive regulation of GTPase activity [ISS]
- positive regulation of T cell activation [ISS]
- positive regulation of release of sequestered calcium ion into cytosol [ISS]
- retinal cone cell development [ISS]
- single organismal cell-cell adhesion [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
G-protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global view of GPCR-mediated signaling and to identify novel components of their pathways, we used a modified membrane yeast two-hybrid (MYTH) ... [more]
Mol. Syst. Biol. Dec. 15, 2016; 13(3);918 [Pubmed: 28298427]
Throughput
- High Throughput
Additional Notes
- interaction identified using a modified split-ubiquitin membrane yeast two-hybrid (MYTH) assay
Curated By
- BioGRID