BAIT
CHRND
ACHRD, CMS2A, FCCMS, SCCMS
cholinergic receptor, nicotinic, delta (muscle)
GO Process (8)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
CHRNA1
ACHRA, ACHRD, CHRNA, CMS2A, FCCMS, SCCMS
cholinergic receptor, nicotinic, alpha 1 (muscle)
GO Process (15)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- cation transmembrane transport [IMP, ISS, TAS]
- ion transmembrane transport [TAS]
- muscle cell cellular homeostasis [IMP]
- musculoskeletal movement [IMP]
- neuromuscular junction development [IMP]
- neuromuscular process [IMP]
- neuromuscular synaptic transmission [IMP]
- neuron cellular homeostasis [IMP]
- neuronal action potential [IMP]
- regulation of membrane potential [IMP]
- signal transduction [TAS]
- skeletal muscle contraction [IMP]
- skeletal muscle tissue growth [IMP]
- synaptic transmission [TAS]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Assembly of the nicotinic acetylcholine receptor. The first transmembrane domains of truncated alpha and delta subunits are required for heterodimer formation in vivo.
To investigate the mechanism of assembly of the mouse muscle acetylcholine receptor, we have expressed truncated N-terminal fragments of the alpha and delta subunits in COS cells and have examined their ability to fold, to associate into heterodimers, and to form a ligand-binding site. Truncated fragments of the alpha subunit that include all, part, or none of the first transmembrane ... [more]
J. Biol. Chem. Nov. 01, 1996; 271(44);27575-84 [Pubmed: 8910344]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CHRNA1 CHRND | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | Low | - | BioGRID | - |
Curated By
- BioGRID