BAIT
F2RL1
GPR11, PAR2
coagulation factor II (thrombin) receptor-like 1
GO Process (46)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- T cell activation involved in immune response [ISS]
- chemokine (C-C motif) ligand 2 secretion [IDA]
- chemokine secretion [IDA]
- defense response to virus [IDA]
- establishment of endothelial barrier [IDA]
- interferon-gamma secretion [ISS]
- interleukin-1 beta secretion [IDA]
- interleukin-10 secretion [IDA]
- leukocyte migration [IDA]
- leukocyte proliferation [ISS]
- mature conventional dendritic cell differentiation [IDA, ISS]
- negative regulation of JNK cascade [IDA]
- negative regulation of chemokine secretion [IDA]
- negative regulation of toll-like receptor 3 signaling pathway [IMP]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- neutrophil activation [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA, ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of Rho protein signal transduction [IMP, ISS]
- positive regulation of actin filament depolymerization [IDA]
- positive regulation of cell migration [ISS]
- positive regulation of chemotaxis [ISS]
- positive regulation of cytokine secretion involved in immune response [IDA]
- positive regulation of cytosolic calcium ion concentration [IDA, ISS]
- positive regulation of eosinophil degranulation [IDA]
- positive regulation of glomerular filtration [ISS]
- positive regulation of interleukin-6 secretion [IDA]
- positive regulation of interleukin-8 secretion [IDA]
- positive regulation of leukocyte chemotaxis [IDA]
- positive regulation of neutrophil mediated killing of gram-negative bacterium [IDA]
- positive regulation of phagocytosis, engulfment [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of positive chemotaxis [IDA]
- positive regulation of pseudopodium assembly [ISS]
- positive regulation of renin secretion into blood stream [ISS]
- positive regulation of superoxide anion generation [IDA]
- positive regulation of toll-like receptor 2 signaling pathway [IMP]
- positive regulation of toll-like receptor 3 signaling pathway [IMP]
- positive regulation of toll-like receptor 4 signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of vasodilation [ISS]
- regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- regulation of JNK cascade [IDA]
- regulation of blood coagulation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC1A4
ASCT1, SATT
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
GO Process (15)
GO Function (8)
GO Component (9)
Gene Ontology Biological Process
- L-alanine transport [IDA]
- L-cystine transport [IDA]
- L-serine transport [IDA]
- amino acid transport [TAS]
- chloride transmembrane transport [IDA]
- chloride transport [IDA]
- cognition [IMP]
- glutamine transport [TAS]
- hydroxyproline transport [IDA]
- ion transport [TAS]
- proline transmembrane transport [IDA]
- proline transport [IDA]
- synaptic transmission, glutamatergic [NAS]
- threonine transport [IDA]
- transmembrane transport [TAS]
Gene Ontology Molecular Function- L-alanine transmembrane transporter activity [IDA]
- L-cystine transmembrane transporter activity [IDA]
- L-glutamine transmembrane transporter activity [TAS]
- L-hydroxyproline transmembrane transporter activity [IDA]
- L-proline transmembrane transporter activity [IDA]
- L-serine transmembrane transporter activity [IDA]
- L-threonine transmembrane transporter activity [IDA]
- chloride channel activity [IDA]
- L-alanine transmembrane transporter activity [IDA]
- L-cystine transmembrane transporter activity [IDA]
- L-glutamine transmembrane transporter activity [TAS]
- L-hydroxyproline transmembrane transporter activity [IDA]
- L-proline transmembrane transporter activity [IDA]
- L-serine transmembrane transporter activity [IDA]
- L-threonine transmembrane transporter activity [IDA]
- chloride channel activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
G-protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global view of GPCR-mediated signaling and to identify novel components of their pathways, we used a modified membrane yeast two-hybrid (MYTH) ... [more]
Mol. Syst. Biol. Dec. 15, 2016; 13(3);918 [Pubmed: 28298427]
Throughput
- High Throughput
Additional Notes
- interaction identified using a modified split-ubiquitin membrane yeast two-hybrid (MYTH) assay
Curated By
- BioGRID