BAIT
FZD7
FzE3
frizzled class receptor 7
GO Process (14)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- canonical Wnt signaling pathway [IDA, IMP]
- cellular response to retinoic acid [ISS]
- mesenchymal to epithelial transition [IMP]
- negative regulation of cell-substrate adhesion [IMP]
- negative regulation of ectodermal cell fate specification [IMP]
- neuron differentiation [ISS]
- non-canonical Wnt signaling pathway via JNK cascade [IMP]
- positive regulation of JNK cascade [IC]
- positive regulation of epithelial cell proliferation involved in wound healing [IMP]
- positive regulation of phosphorylation [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- regulation of catenin import into nucleus [IMP]
- regulation of transcription, DNA-templated [IMP]
- stem cell maintenance [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ADCY1
AC1, DFNB44
adenylate cyclase 1 (brain)
GO Process (16)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- activation of phospholipase C activity [TAS]
- activation of protein kinase A activity [TAS]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [TAS]
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [TAS]
- cellular response to glucagon stimulus [TAS]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- regulation of circadian rhythm [ISS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
- transmembrane transport [TAS]
- water transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
G-protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global view of GPCR-mediated signaling and to identify novel components of their pathways, we used a modified membrane yeast two-hybrid (MYTH) ... [more]
Mol. Syst. Biol. Dec. 15, 2016; 13(3);918 [Pubmed: 28298427]
Throughput
- High Throughput
Additional Notes
- interaction identified using a modified split-ubiquitin membrane yeast two-hybrid (MYTH) assay
Curated By
- BioGRID