BAIT
HRH1
H1-R, hisH1
histamine receptor H1
GO Process (6)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISS]
- cellular response to histamine [ISS]
- inflammatory response [TAS]
- inositol phosphate-mediated signaling [ISS]
- phospholipase C-activating G-protein coupled receptor signaling pathway [TAS]
- positive regulation of inositol trisphosphate biosynthetic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ATP6V0A1
ATP6N1, ATP6N1A, Stv1, VPP1, Vph1, a1
ATPase, H+ transporting, lysosomal V0 subunit a1
GO Process (9)
GO Function (3)
GO Component (9)
Gene Ontology Biological Process
- ATP synthesis coupled proton transport [IBA]
- cellular iron ion homeostasis [TAS]
- insulin receptor signaling pathway [TAS]
- interaction with host [TAS]
- phagosome maturation [TAS]
- transferrin transport [TAS]
- transmembrane transport [TAS]
- vacuolar acidification [IBA]
- vacuolar proton-transporting V-type ATPase complex assembly [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
G-protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global view of GPCR-mediated signaling and to identify novel components of their pathways, we used a modified membrane yeast two-hybrid (MYTH) ... [more]
Mol. Syst. Biol. Dec. 15, 2016; 13(3);918 [Pubmed: 28298427]
Throughput
- High Throughput
Additional Notes
- interaction identified using a modified split-ubiquitin membrane yeast two-hybrid (MYTH) assay
Curated By
- BioGRID