BAIT
HTR2B
5-HT(2B), 5-HT2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
GO Process (35)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [IMP]
- G-protein coupled receptor signaling pathway [IMP]
- activation of phospholipase C activity [IDA]
- cGMP biosynthetic process [IDA]
- calcium-mediated signaling [IMP]
- cardiac muscle hypertrophy [ISS]
- cellular calcium ion homeostasis [IDA]
- cellular response to temperature stimulus [ISS]
- embryonic morphogenesis [ISS]
- heart morphogenesis [ISS]
- intestine smooth muscle contraction [IMP]
- negative regulation of apoptotic process [ISS]
- negative regulation of autophagy [IMP]
- negative regulation of cell death [IMP]
- neural crest cell differentiation [ISS]
- neural crest cell migration [ISS]
- phosphatidylinositol 3-kinase signaling [IDA]
- phosphorylation [IMP]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of cell division [ISS]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of cytokine production [IDA]
- positive regulation of cytokine secretion [ISS]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of nitric-oxide synthase activity [IDA]
- positive regulation of phosphatidylinositol biosynthetic process [IDA]
- protein kinase C signaling [IMP]
- protein kinase C-activating G-protein coupled receptor signaling pathway [ISS]
- regulation of behavior [IMP]
- release of sequestered calcium ion into cytosol [IDA, IMP]
- response to drug [IDA]
- serotonin receptor signaling pathway [IMP]
- vasoconstriction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PLLP
PMLP, TM4SF11
plasmolipin
GO Process (0)
GO Function (0)
GO Component (1)
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
G-protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global view of GPCR-mediated signaling and to identify novel components of their pathways, we used a modified membrane yeast two-hybrid (MYTH) ... [more]
Mol. Syst. Biol. Dec. 15, 2016; 13(3);918 [Pubmed: 28298427]
Throughput
- High Throughput
Additional Notes
- interaction identified using a modified split-ubiquitin membrane yeast two-hybrid (MYTH) assay
Curated By
- BioGRID