BAIT
CHRM5
HM5
cholinergic receptor, muscarinic 5
GO Process (4)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ERCC1
COFS4, RAD10, UV20
excision repair cross-complementation group 1
GO Process (11)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IDA]
- DNA recombination [IGI]
- DNA repair [TAS]
- mitotic recombination [IMP]
- negative regulation of telomere maintenance [IMP]
- nucleotide-excision repair [IDA, IGI, TAS]
- nucleotide-excision repair, DNA damage removal [TAS]
- nucleotide-excision repair, DNA incision, 3'-to lesion [IMP]
- nucleotide-excision repair, DNA incision, 5'-to lesion [IMP]
- response to oxidative stress [IMP]
- transcription-coupled nucleotide-excision repair [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
G-protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global view of GPCR-mediated signaling and to identify novel components of their pathways, we used a modified membrane yeast two-hybrid (MYTH) ... [more]
Mol. Syst. Biol. Dec. 15, 2016; 13(3);918 [Pubmed: 28298427]
Throughput
- High Throughput
Additional Notes
- interaction identified using a modified split-ubiquitin membrane yeast two-hybrid (MYTH) assay
Curated By
- BioGRID