BAIT
CA2
CA-II, CAC, CAII, Car2, HEL-76
carbonic anhydrase II
GO Process (6)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC4A1
AE1, BND3, CD233, DI, EMPB3, EPB3, FR, RTA1A, SW, WD, WD1, WR
solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
GO Process (7)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function- anion transmembrane transporter activity [TAS]
- anion:anion antiporter activity [IDA]
- ankyrin binding [IPI]
- bicarbonate transmembrane transporter activity [IDA]
- chloride transmembrane transporter activity [ISS]
- inorganic anion exchanger activity [IDA, TAS]
- protein anchor [TAS]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- anion transmembrane transporter activity [TAS]
- anion:anion antiporter activity [IDA]
- ankyrin binding [IPI]
- bicarbonate transmembrane transporter activity [IDA]
- chloride transmembrane transporter activity [ISS]
- inorganic anion exchanger activity [IDA, TAS]
- protein anchor [TAS]
- protein binding [IPI]
- protein homodimerization activity [IPI]
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers.
The cytoplasmic carboxyl-terminal domain of AE1, the plasma membrane chloride/bicarbonate exchanger of erythrocytes, contains a binding site for carbonic anhydrase II (CAII). To examine the physiological role of the AE1/CAII interaction, anion exchange activity of transfected HEK293 cells was monitored by following the changes in intracellular pH associated with AE1-mediated bicarbonate transport. AE1-mediated chloride/bicarbonate exchange was reduced 50-60% by inhibition ... [more]
J. Biol. Chem. Dec. 21, 2001; 276(51);47886-94 [Pubmed: 11606574]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SLC4A1 CA2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| SLC4A1 CA2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| SLC4A1 CA2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID