IRS1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- cellular response to insulin stimulus [IMP]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- glucose homeostasis [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [IDA, IMP, IPI, TAS]
- insulin-like growth factor receptor signaling pathway [IPI]
- negative regulation of insulin receptor signaling pathway [ISS]
- negative regulation of insulin secretion [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol 3-kinase signaling [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of cell proliferation [NAS]
- positive regulation of fatty acid beta-oxidation [IMP]
- positive regulation of glucose import [IMP]
- positive regulation of glucose import in response to insulin stimulus [IDA]
- positive regulation of glucose metabolic process [IMP]
- positive regulation of glycogen biosynthetic process [IMP, NAS]
- positive regulation of insulin receptor signaling pathway [ISS]
- positive regulation of phosphatidylinositol 3-kinase activity [ISS]
- response to insulin [IDA]
- response to peptide hormone [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
JAK3
Gene Ontology Biological Process
- B cell differentiation [IBA, ISS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- STAT protein import into nucleus [TAS]
- T cell homeostasis [IBA, ISS, TAS]
- cell migration [IBA]
- enzyme linked receptor protein signaling pathway [ISS]
- erythrocyte differentiation [IBA]
- inflammatory response [IBA]
- innate immune response [IBA]
- interleukin-4-mediated signaling pathway [IDA]
- intracellular signal transduction [ISS]
- negative regulation of FasL biosynthetic process [ISS]
- negative regulation of T cell activation [ISS]
- negative regulation of T-helper 1 cell differentiation [ISS]
- negative regulation of dendritic cell cytokine production [ISS]
- negative regulation of interleukin-10 production [ISS]
- negative regulation of interleukin-12 production [ISS]
- negative regulation of thymocyte apoptotic process [ISS]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of T cell proliferation [IBA]
- protein phosphorylation [TAS]
- regulation of T cell apoptotic process [ISS]
- regulation of apoptotic process [IBA]
- response to interleukin-15 [TAS]
- response to interleukin-2 [TAS]
- response to interleukin-4 [IDA]
- response to interleukin-9 [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- tyrosine phosphorylation of STAT protein [IBA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases.
The signaling molecules insulin receptor substrate (IRS)-1 and the newly described IRS-2 (4PS) molecule are major insulin and interleukin 4 (IL-4)-dependent phosphoproteins. We report here that IL-2, IL-7, and IL-15, as well as IL-4, rapidly stimulate the tyrosine phosphorylation of IRS-1 and IRS-2 in human peripheral blood T cells, NK cells, and in lymphoid cell lines. In addition, we show ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID