BAIT
TAAR1
TA1, TAR1, TRAR1, RP11-295F4.9
trace amine associated receptor 1
GO Process (0)
GO Function (1)
GO Component (1)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GRIK1
EAA3, EEA3, GLR5, GLUR5, GluK1
glutamate receptor, ionotropic, kainate 1
GO Process (9)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- central nervous system development [TAS]
- glutamate receptor signaling pathway [TAS]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IDA, TAS]
- nervous system development [TAS]
- regulation of synaptic transmission, glutamatergic [TAS]
- synaptic transmission [TAS]
- synaptic transmission, glutamatergic [IBA]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
G-protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global view of GPCR-mediated signaling and to identify novel components of their pathways, we used a modified membrane yeast two-hybrid (MYTH) ... [more]
Mol. Syst. Biol. Dec. 15, 2016; 13(3);918 [Pubmed: 28298427]
Throughput
- High Throughput
Additional Notes
- interaction identified using a modified split-ubiquitin membrane yeast two-hybrid (MYTH) assay
Curated By
- BioGRID