BAIT
EPAS1
ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73
endothelial PAS domain protein 1
GO Process (6)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- cellular response to hypoxia [IDA, TAS]
- myoblast fate commitment [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- response to hypoxia [IDA]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HILPDA
C7orf68, HIG-2, HIG2
hypoxia inducible lipid droplet-associated
GO Process (5)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.
Clear-cell carcinomas (CCCs) are a histological group of highly aggressive malignancies commonly originating in the kidney and ovary. CCCs are distinguished by aberrant lipid and glycogen accumulation and are refractory to a broad range of anti-cancer therapies. Here we identify an intrinsic vulnerability to ferroptosis associated with the unique metabolic state in CCCs. This vulnerability transcends lineage and genetic landscape, ... [more]
Nat Commun Dec. 08, 2018; 10(1);1617 [Pubmed: 30962421]
Throughput
- Low Throughput
Ontology Terms
- cell component: cellular response to drug (GO:0035690)
Additional Notes
- CRISPR method
- overexpression restores ferroptosis-inducing chemical sensitivity in a CRISPR generated HIF2alpha mutant
Curated By
- BioGRID