A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.

Zou Y, Palte MJ, Deik AA, Li H, Eaton JK, Wang W, Tseng YY, Deasy R, Kost-Alimova M, Dancik V, Leshchiner ES, Viswanathan VS, Signoretti S, Choueiri TK, Boehm JS, Wagner BK, Doench JG, Clish CB, Clemons PA, Schreiber SL

Clear-cell carcinomas (CCCs) are a histological group of highly aggressive malignancies commonly originating in the kidney and ovary. CCCs are distinguished by aberrant lipid and glycogen accumulation and are refractory to a broad range of anti-cancer therapies. Here we identify an intrinsic vulnerability to ferroptosis associated with the unique metabolic state in CCCs. This vulnerability transcends lineage and genetic landscape, ... [more]

Nat Commun Dec. 08, 2018; 10(1);1617 [Pubmed: 30962421]

Throughput

Low Throughput

Ontology Terms

cell component: cellular response to drug (GO:0035690)

Additional Notes

CRISPR method
overexpression restores ferroptosis-inducing chemical sensitivity in a CRISPR generated HIF2alpha mutant

Curated By

BioGRID

Interaction Summary

EPAS1

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA binding [IGI]histone acetyltransferase binding [IPI]protein binding [IPI]protein heterodimerization activity [IPI]sequence-specific DNA binding [IDA]transcription factor binding [IPI]

Gene Ontology Cellular Component

G0S2