BAIT
FITM2
AI414861, D930001I22Rik, Fit2, RP23-36P22.6
fat storage-inducing transmembrane protein 2
GO Process (7)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Mus musculus
PREY
SCN8A
AI853486, C630029C19Rik, NaCh6, Nav1.6, dmu, med, mnd-2, mnd2, nmf2, nmf335, nmf58, nur14, seal
sodium channel, voltage-gated, type VIII, alpha
GO Process (12)
GO Function (3)
GO Component (10)
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- adult walking behavior [IMP]
- locomotory behavior [IMP]
- membrane depolarization during action potential [IBA]
- muscle organ development [IMP]
- neuromuscular process [IMP]
- neuronal action potential [IBA, ISO]
- regulation of ion transmembrane transport [NAS]
- response to toxic substance [IDA]
- sensory perception of sound [IMP]
- sodium ion transmembrane transport [ISO, NAS]
- sodium ion transport [ISO, NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.
The genetic circuits that allow cancer cells to evade destruction by the host immune system remain poorly understood1-3. Here, to identify a phenotypically robust core set of genes and pathways that enable cancer cells to evade killing mediated by cytotoxic TÂ lymphocytes (CTLs), we performed genome-wide CRISPR screens across a panel of genetically diverse mouse cancer cell lines that were cultured ... [more]
Nature Oct. 01, 2020; 586(7827);120-126 [Pubmed: 32968282]
Throughput
- Low Throughput
Ontology Terms
- phenotype: decreased cell proliferation (MP:0000352)
Additional Notes
- CRISPR GI screen
- Cell Line: Renca
- Experimental Setup: Cytokin Exposure: IFNgamma (10ng/ml)
- GIST: A-phenotypic negative genetic interaction
- Library: mTKO
- Significance Threshold: FDR<0.05
Curated By
- BioGRID