BAIT
FITM2
AI414861, D930001I22Rik, Fit2, RP23-36P22.6
fat storage-inducing transmembrane protein 2
GO Process (7)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Mus musculus
PREY
ATG7
1810013K23Rik, Agp7, Apg7l, Atg7l, Gm21553
autophagy related 7
GO Process (37)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- C-terminal protein lipidation [IBA]
- adult walking behavior [IMP]
- autophagy [IMP]
- cardiac muscle cell development [IMP]
- cellular amino acid metabolic process [IMP]
- cellular response to hyperoxia [ISO]
- cellular response to nitrogen starvation [IBA]
- cellular response to starvation [ISO]
- central nervous system neuron axonogenesis [IMP]
- cerebellar Purkinje cell layer development [IMP]
- cerebral cortex development [IMP]
- late nucleophagy [IBA]
- liver development [IMP]
- macroautophagy [IBA]
- membrane organization [IMP]
- mitochondrion degradation [IBA]
- mitochondrion organization [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of histone H4-K16 acetylation [IMP]
- negative stranded viral RNA replication [IMP]
- neurological system process [IMP]
- neuron projection development [IMP]
- organelle organization [IMP]
- piecemeal microautophagy of nucleus [IBA]
- positive regulation of apoptotic process [ISO]
- positive regulation of autophagy [ISO]
- positive regulation of macroautophagy [ISO]
- positive regulation of mucus secretion [IMP]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein modification process [IDA, ISO]
- post-embryonic development [IMP]
- protein catabolic process [IMP]
- protein lipidation [ISO]
- protein modification by small protein conjugation [IMP]
- pyramidal neuron development [IMP]
- regulation of protein ubiquitination [IMP]
- response to starvation [IMP]
Gene Ontology Molecular Function
Mus musculus
Positive Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.
The genetic circuits that allow cancer cells to evade destruction by the host immune system remain poorly understood1-3. Here, to identify a phenotypically robust core set of genes and pathways that enable cancer cells to evade killing mediated by cytotoxic TÂ lymphocytes (CTLs), we performed genome-wide CRISPR screens across a panel of genetically diverse mouse cancer cell lines that were cultured ... [more]
Nature Oct. 01, 2020; 586(7827);120-126 [Pubmed: 32968282]
Throughput
- Low Throughput
Ontology Terms
- phenotype: increased cell proliferation (MP:0000351)
Additional Notes
- CRISPR GI screen
- Cell Line: Renca
- Experimental Setup: Cytokine Exposure: IFNgamma (10ng/ml)
- GIST: A-phenotypic positive genetic interaction
- Library: mTKO
- Significance Threshold: FDR<0.05
Curated By
- BioGRID