BAIT
FITM2
AI414861, D930001I22Rik, Fit2, RP23-36P22.6
fat storage-inducing transmembrane protein 2
GO Process (7)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Mus musculus
PREY
ATP7A
MNK, RP23-186F4.3
ATPase, Cu++ transporting, alpha polypeptide
GO Process (47)
GO Function (6)
GO Component (16)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- ATP metabolic process [IMP]
- T-helper cell differentiation [IMP]
- blood vessel development [IMP]
- blood vessel remodeling [IMP]
- cartilage development [IMP]
- catecholamine metabolic process [IMP]
- cellular copper ion homeostasis [IGI, IMP, ISO]
- central nervous system neuron development [IMP]
- cerebellar Purkinje cell differentiation [IMP]
- collagen fibril organization [IMP]
- copper ion export [IDA, IMP]
- copper ion import [IMP]
- copper ion transport [IDA, IMP, ISO]
- dendrite morphogenesis [IMP]
- detoxification of copper ion [IMP]
- dopamine metabolic process [IMP]
- elastic fiber assembly [IMP]
- elastin biosynthetic process [IMP]
- epinephrine metabolic process [IMP]
- extracellular matrix organization [IMP]
- hair follicle morphogenesis [IMP]
- hindlimb morphogenesis [IMP]
- locomotory behavior [IMP]
- lung alveolus development [IMP]
- mitochondrion organization [IMP]
- negative regulation of metalloenzyme activity [IMP]
- negative regulation of neuron apoptotic process [IMP]
- neuron projection morphogenesis [IMP]
- norepinephrine biosynthetic process [IMP]
- norepinephrine metabolic process [IMP]
- peptidyl-lysine modification [IMP]
- pigmentation [IMP]
- plasma membrane copper ion transport [ISO]
- positive regulation of catalytic activity [IDA, IMP]
- positive regulation of metalloenzyme activity [IMP]
- positive regulation of oxidoreductase activity [ISO]
- pyramidal neuron development [IMP]
- regulation of gene expression [IMP]
- regulation of oxidative phosphorylation [IMP]
- release of cytochrome c from mitochondria [IMP]
- removal of superoxide radicals [IMP]
- response to copper ion [ISO]
- serotonin metabolic process [IMP]
- skin development [IMP]
- tryptophan metabolic process [IMP]
- tyrosine metabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- basolateral plasma membrane [ISO]
- brush border membrane [ISO]
- cell [IGI]
- cytoplasmic vesicle [IDA]
- endoplasmic reticulum [ISO]
- integral component of membrane [ISO]
- late endosome [ISO]
- membrane [IDA, ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- secretory granule [ISO]
- trans-Golgi network [IDA, ISO]
- trans-Golgi network transport vesicle [ISO]
Mus musculus
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.
The genetic circuits that allow cancer cells to evade destruction by the host immune system remain poorly understood1-3. Here, to identify a phenotypically robust core set of genes and pathways that enable cancer cells to evade killing mediated by cytotoxic TÂ lymphocytes (CTLs), we performed genome-wide CRISPR screens across a panel of genetically diverse mouse cancer cell lines that were cultured ... [more]
Nature Oct. 01, 2020; 586(7827);120-126 [Pubmed: 32968282]
Throughput
- Low Throughput
Ontology Terms
- decreased cell proliferation (MP:0000352)
Additional Notes
- CRISPR GI screen
- Cell Line: Renca
- Experimental Setup: Cytotoxic T cell exposure
- GIST: A-phenotypic negative genetic interaction
- Library: mTKO
- Significance Threshold: FDR<0.05
Curated By
- BioGRID