ATG12
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ATG7
Gene Ontology Biological Process
- C-terminal protein lipidation [IBA]
- adult walking behavior [IMP]
- autophagy [IMP]
- cardiac muscle cell development [IMP]
- cellular amino acid metabolic process [IMP]
- cellular response to hyperoxia [ISO]
- cellular response to nitrogen starvation [IBA]
- cellular response to starvation [ISO]
- central nervous system neuron axonogenesis [IMP]
- cerebellar Purkinje cell layer development [IMP]
- cerebral cortex development [IMP]
- late nucleophagy [IBA]
- liver development [IMP]
- macroautophagy [IBA]
- membrane organization [IMP]
- mitochondrion degradation [IBA]
- mitochondrion organization [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of histone H4-K16 acetylation [IMP]
- negative stranded viral RNA replication [IMP]
- neurological system process [IMP]
- neuron projection development [IMP]
- organelle organization [IMP]
- piecemeal microautophagy of nucleus [IBA]
- positive regulation of apoptotic process [ISO]
- positive regulation of autophagy [ISO]
- positive regulation of macroautophagy [ISO]
- positive regulation of mucus secretion [IMP]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein modification process [IDA, ISO]
- post-embryonic development [IMP]
- protein catabolic process [IMP]
- protein lipidation [ISO]
- protein modification by small protein conjugation [IMP]
- pyramidal neuron development [IMP]
- regulation of protein ubiquitination [IMP]
- response to starvation [IMP]
Gene Ontology Molecular Function
Positive Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.
The genetic circuits that allow cancer cells to evade destruction by the host immune system remain poorly understood1-3. Here, to identify a phenotypically robust core set of genes and pathways that enable cancer cells to evade killing mediated by cytotoxic TÂ lymphocytes (CTLs), we performed genome-wide CRISPR screens across a panel of genetically diverse mouse cancer cell lines that were cultured ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: increased cell proliferation (MP:0000351)
Additional Notes
- CRISPR GI screen
- Cell Line: Renca
- Experimental Setup: Cytotoxic T cell exposure
- Experimental Setup: TNF exposure
- GIST: A-phenotypic positive genetic interaction
- Library: mTKO
- Significance Threshold: FDR<0.05
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ATG7 ATG12 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| ATG12 ATG7 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.9335 | BioGRID | 2667019 |
Curated By
- BioGRID