Publication

Mapping of a defined neurocan binding site to distinct domains of tenascin-C.

Rauch U, Clement A, Retzler C, Froehlich L, Faessler R, Goehring W, Faissner A

Neurocan is a member of the aggrecan family of proteoglycans which are characterized by NH2-terminal domains binding hyaluronan, and COOH-terminal domains containing C-type lectin-like modules. To detect and enhance the affinity for complementary ligands of neurocan, the COOH-terminal neurocan domain was fused with the NH2-terminal region of tenascin-C, which contains the hexamerization domain of this extracellular matrix glycoprotein. The fusion ... [more]

Throughput

• Low Throughput

Curated By

• BioGRID