BAIT
ATG12
4931423H11Rik, A330058M13Rik, Apg12l, Atg12l
autophagy related 12
GO Process (6)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HNRNPH1
AI642080, E430005G16Rik, Hnrnph, Hnrph1, RP23-121P11.1
heterogeneous nuclear ribonucleoprotein H1
GO Process (1)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.
The genetic circuits that allow cancer cells to evade destruction by the host immune system remain poorly understood1-3. Here, to identify a phenotypically robust core set of genes and pathways that enable cancer cells to evade killing mediated by cytotoxic TÂ lymphocytes (CTLs), we performed genome-wide CRISPR screens across a panel of genetically diverse mouse cancer cell lines that were cultured ... [more]
Nature Oct. 01, 2020; 586(7827);120-126 [Pubmed: 32968282]
Throughput
- Low Throughput
Ontology Terms
- phenotype: decreased cell proliferation (MP:0000352)
Additional Notes
- CRISPR GI screen
- Cell Line: Renca
- Experimental Setup: TNF exposure
- GIST: A-phenotypic negative genetic interaction
- Library: mTKO
- Significance Threshold: FDR<0.05
Curated By
- BioGRID