BAIT
ATG12
4931423H11Rik, A330058M13Rik, Apg12l, Atg12l
autophagy related 12
GO Process (6)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SHARPIN
0610041B22Rik, AW121341, RBCKL1, SIPL1, cpdm
SHANK-associated RH domain interacting protein
GO Process (10)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- apoptotic nuclear changes [IMP]
- epidermis development [IMP]
- keratinization [IMP]
- mitochondrion organization [IMP]
- negative regulation of inflammatory response [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP, ISO]
- protein homooligomerization [ISO]
- protein linear polyubiquitination [ISO]
- regulation of CD40 signaling pathway [ISO]
- regulation of tumor necrosis factor-mediated signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Positive Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.
The genetic circuits that allow cancer cells to evade destruction by the host immune system remain poorly understood1-3. Here, to identify a phenotypically robust core set of genes and pathways that enable cancer cells to evade killing mediated by cytotoxic TÂ lymphocytes (CTLs), we performed genome-wide CRISPR screens across a panel of genetically diverse mouse cancer cell lines that were cultured ... [more]
Nature Oct. 01, 2020; 586(7827);120-126 [Pubmed: 32968282]
Throughput
- Low Throughput
Ontology Terms
- phenotype: increased cell proliferation (MP:0000351)
Additional Notes
- CRISPR GI screen
- Cell Line: Renca
- Experimental Setup: TNF exposure
- GIST: A-phenotypic positive genetic interaction
- Library: mTKO
- Significance Threshold: FDR<0.05
Curated By
- BioGRID