MYO5A
Gene Ontology Biological Process
- actin filament-based movement [NAS]
- cellular protein metabolic process [TAS]
- cellular response to insulin stimulus [ISS]
- membrane organization [TAS]
- post-Golgi vesicle-mediated transport [IMP]
- protein localization to plasma membrane [ISS]
- regulation of Golgi organization [IMP]
- transport [NAS]
- vesicle transport along actin filament [IMP]
- vesicle-mediated transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin filament [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- early endosome [IDA]
- endoplasmic reticulum [IDA]
- extracellular vesicular exosome [IDA]
- filopodium tip [IDA]
- growth cone [NAS]
- insulin-responsive compartment [ISS]
- late endosome [IDA]
- lysosome [IDA]
- membrane [IDA]
- neuron projection [NAS]
- peroxisome [IDA]
- recycling endosome [IDA]
- ruffle [IDA]
- vesicle [IDA]
RAB27A
Gene Ontology Biological Process
- GTP catabolic process [IBA]
- Rab protein signal transduction [IBA]
- antigen processing and presentation [IMP]
- cellular protein metabolic process [TAS]
- complement-dependent cytotoxicity [IMP]
- exocytosis [IDA]
- exosomal secretion [IMP]
- intracellular protein transport [IBA]
- melanosome localization [IMP]
- melanosome transport [IBA]
- multivesicular body organization [IMP]
- multivesicular body sorting pathway [IMP]
- positive regulation of constitutive secretory pathway [IMP]
- positive regulation of exocytosis [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of phagocytosis [IMP]
- positive regulation of reactive oxygen species biosynthetic process [IMP]
- positive regulation of regulated secretory pathway [IGI, IMP]
- protein secretion [IBA]
- synaptic vesicle transport [TAS]
- vesicle docking involved in exocytosis [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Rab27a is an essential component of melanosome receptor for myosin Va.
Melanocytes that lack the GTPase Rab27a (ashen) are disabled in myosin Va-dependent melanosome capture because the association of the myosin with the melanosome surface depends on the presence of this resident melanosomal membrane protein. One interpretation of these observations is that Rab27a functions wholly or in part as the melanosome receptor for myosin Va (Myo5a). Herein, we show that the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAB27A MYO5A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID