BAIT
COPA
HEP-COP
coatomer protein complex, subunit alpha
GO Process (4)
GO Function (0)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
ARFGAP1
ARF1GAP, HRIHFB2281, RP11-261N11.1
ADP-ribosylation factor GTPase activating protein 1
GO Process (7)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- COPI coating of Golgi vesicle [TAS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum unfolded protein response [TAS]
- membrane organization [TAS]
- positive regulation of GTPase activity [IDA]
- retrograde vesicle-mediated transport, Golgi to ER [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat.
The role of GTPase-activating protein (GAP) that deactivates ADP-ribosylation factor 1 (ARF1) during the formation of coat protein I (COPI) vesicles has been unclear. GAP is originally thought to antagonize vesicle formation by triggering uncoating, but later studies suggest that GAP promotes cargo sorting, a process that occurs during vesicle formation. Recent models have attempted to reconcile these seemingly contradictory ... [more]
J. Cell Biol. Oct. 14, 2002; 159(1);69-78 [Pubmed: 12379802]
Throughput
- Low Throughput
Curated By
- BioGRID