PLG
Gene Ontology Biological Process
- blood coagulation [IMP, TAS]
- cellular protein metabolic process [TAS]
- extracellular matrix disassembly [IDA, TAS]
- extracellular matrix organization [TAS]
- fibrinolysis [TAS]
- negative regulation of cell proliferation [TAS]
- negative regulation of cell-cell adhesion mediated by cadherin [TAS]
- negative regulation of cell-substrate adhesion [IDA]
- negative regulation of fibrinolysis [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of fibrinolysis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CHGA
Gene Ontology Biological Process
Gene Ontology Cellular Component
Biochemical Activity (Proteolytic Processing)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Proteolytic cleavage of chromogranin A (CgA) by plasmin. Selective liberation of a specific bioactive CgA fragment that regulates catecholamine release.
Chromogranin A (CgA), the major soluble protein in catecholamine storage vesicles, serves as a prohormone that is cleaved into bioactive peptides that inhibit catecholamine release, providing an autocrine, negative feedback mechanism for regulating catecholamine responses during stress. However, the proteases responsible for the processing of CgA and release of bioactive peptides have not been established. Recently, we found that chromaffin ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID