BAIT
UBE2I
5830467E05Rik, F830028O17Rik, UBC9, Ubce2i, Ubce9
ubiquitin-conjugating enzyme E2I
GO Process (10)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- cellular protein modification process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of intracellular steroid hormone receptor signaling pathway [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein sumoylation [IBA, ISO]
- protein ubiquitination [IBA, ISO]
- regulation of receptor activity [ISO]
Gene Ontology Molecular Function- HLH domain binding [IPI]
- RING-like zinc finger domain binding [ISO]
- SUMO transferase activity [IBA, ISO]
- bHLH transcription factor binding [ISO]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- transcription factor binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- HLH domain binding [IPI]
- RING-like zinc finger domain binding [ISO]
- SUMO transferase activity [IBA, ISO]
- bHLH transcription factor binding [ISO]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- transcription factor binding [ISO]
- ubiquitin-protein transferase activity [ISO]
Mus musculus
PREY
FAS
AI196731, APO1, APT1, CD95, TNFR6, Tnfrsf6, lpr
Fas (TNF receptor superfamily member 6)
GO Process (39)
GO Function (6)
GO Component (18)
Gene Ontology Biological Process
- B cell mediated immunity [IMP]
- T cell homeostasis [IMP]
- activation-induced cell death of T cells [IDA, IMP]
- apoptotic process [IMP, ISO]
- apoptotic signaling pathway [IDA, ISO]
- cellular response to hyperoxia [ISO]
- cellular response to lithium ion [IMP]
- dendrite regeneration [ISO]
- extrinsic apoptotic signaling pathway [IDA, IMP, ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- extrinsic apoptotic signaling pathway via death domain receptors [IDA, IGI, IMP]
- gene expression [IMP]
- hepatocyte apoptotic process [IGI]
- immunoglobulin production [IMP]
- inflammatory cell apoptotic process [IDA, IMP]
- motor neuron apoptotic process [IMP]
- necroptotic signaling pathway [IGI, ISO]
- negative regulation of B cell activation [IMP]
- negative regulation of apoptotic process [IDA]
- negative thymic T cell selection [IMP]
- neuron apoptotic process [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell death [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- positive regulation of protein homooligomerization [IDA]
- positive regulation of release of cytochrome c from mitochondria [IC]
- protein homooligomerization [IDA]
- regulation of apoptotic process [ISO]
- regulation of cell proliferation [ISO]
- regulation of gene expression [ISO]
- regulation of lymphocyte differentiation [IMP]
- regulation of myeloid cell differentiation [IMP]
- renal system process [IMP]
- response to glucocorticoid [IMP]
- response to toxic substance [IMP]
- spleen development [IMP]
- transformed cell apoptotic process [IDA]
- tumor necrosis factor-mediated signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- CD95 death-inducing signaling complex [IDA, ISO]
- apical dendrite [ISO]
- apical plasma membrane [ISO]
- cell surface [IDA, ISO]
- cytoplasm [ISO]
- death-inducing signaling complex [ISO]
- external side of plasma membrane [IDA]
- extracellular region [IDA]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- membrane raft [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- sarcolemma [ISO]
- secretory granule [ISO]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interaction of Fas(Apo-1/CD95) with proteins implicated in the ubiquitination pathway.
Fas(Apo-1/CD95), a receptor belonging to the tumor necrosis factor receptor family, induces apoptosis when triggered by Fas ligand. Upon its activation, the cytoplasmic domain of Fas binds several proteins which transmit the death signal. We used the yeast two-hybrid screen to isolate Fas-associated proteins. Here we report that the ubiquitin-conjugating enzyme UBC9 binds to Fas at the interface between the ... [more]
FEBS Lett. Jul. 21, 1997; 412(1);102-6 [Pubmed: 9257699]
Throughput
- Low Throughput
Curated By
- BioGRID