SP1
Gene Ontology Biological Process
- cellular lipid metabolic process [TAS]
- gene expression [TAS]
- positive regulation by host of viral transcription [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, TAS]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of transcription, DNA-templated [IDA]
- small molecule metabolic process [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- HMG box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II repressing transcription factor binding [ISS]
- bHLH transcription factor binding [ISS]
- core promoter sequence-specific DNA binding [ISS]
- double-stranded DNA binding [IDA]
- histone deacetylase binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- HMG box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II repressing transcription factor binding [ISS]
- bHLH transcription factor binding [ISS]
- core promoter sequence-specific DNA binding [ISS]
- double-stranded DNA binding [IDA]
- histone deacetylase binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
- nucleoplasm [IDA, TAS]
- nucleus [IC]
NFKB2
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- innate immune response [TAS]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of type I interferon production [TAS]
- regulation of transcription, DNA-templated [IDA]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [TAS]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Interaction of the v-Rel oncoprotein with cellular transcription factor Sp1.
We previously showed that v-Rel, the oncoprotein of the avian retrovirus Rev-T, can increase expression from promoters containing binding sites for the cellular transcription factor Sp1 in chicken embryo fibroblasts (S. Sif, A.J. Capobianco, and T.D. Gilmore, Oncogene 8:2501-2509, 1993). In those experiments, v-Rel appeared to increase the transactivating function of Sp1; that is, v-Rel stimulated transactivation by a GAL4-Sp1 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID