BAIT
PACSIN3
SDPIII
protein kinase C and casein kinase substrate in neurons 3
GO Process (6)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
WASL
N-WASP, NWASP
Wiskott-Aldrich syndrome-like
GO Process (15)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- actin polymerization or depolymerization [TAS]
- axon guidance [TAS]
- cellular component movement [TAS]
- innate immune response [TAS]
- membrane budding [ISS]
- negative regulation of membrane tubulation [IDA]
- nitric oxide metabolic process [TAS]
- positive regulation of clathrin-mediated endocytosis [ISS]
- positive regulation of filopodium assembly [ISS]
- protein complex assembly [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- small molecule metabolic process [TAS]
- vesicle organization [ISS]
- vesicle transport along actin filament [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis.
The PACSINs are a family of cytoplasmic phosphoproteins that play a role in vesicle formation and transport. We report the cloning and cDNA sequencing of PACSIN 3 and the analysis of all three PACSIN isoforms with regard to tissue distribution, ligand binding properties and influence on endocytosis. PACSIN 3 differs from the other family members in having a short proline-rich ... [more]
J. Cell. Sci. Dec. 01, 2000; 113(0);4511-21 [Pubmed: 11082044]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| WASL PACSIN3 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 2711069 |
Curated By
- BioGRID