COL7A1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
LAMA5
Gene Ontology Biological Process
- angiogenesis [NAS]
- cell differentiation [NAS]
- cell migration [IDA]
- cell proliferation [NAS]
- cell recognition [NAS]
- cytoskeleton organization [NAS]
- embryo development [NAS]
- endothelial cell differentiation [NAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- focal adhesion assembly [NAS]
- integrin-mediated signaling pathway [IMP]
- substrate adhesion-dependent cell spreading [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Laminin 5 binds the NC-1 domain of type VII collagen.
Mutational analyses of genes that encode components of the anchoring complex underlying the basolateral surface of external epithelia indicate that this structure is the major element providing for resistance to external friction. Ultrastructurally, laminin 5 (alpha3beta3gamma2; a component of the anchoring filament) appears as a thin filament bridging the hemidesmosome with the anchoring fibrils. Laminin 5 binds the cell surface ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
COL7A1 LAMA5 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID