VAMP3
Gene Ontology Biological Process
- exocytosis [TAS]
- membrane fusion [TAS]
- mucus secretion [IMP]
- negative regulation of secretion by cell [IDA]
- neurotransmitter secretion [IBA]
- positive regulation of immunoglobulin secretion [IMP]
- positive regulation of receptor recycling [ISS]
- protein complex assembly [TAS]
- regulation of histamine secretion by mast cell [IMP]
- retrograde transport, endosome to Golgi [IDA]
- substrate adhesion-dependent cell spreading [ISS]
- vesicle docking involved in exocytosis [TAS]
- vesicle fusion [IBA]
- vesicle-mediated transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
VTI1A
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [IBA, ISS]
- Golgi ribbon formation [IMP]
- Golgi to vacuole transport [IBA]
- intra-Golgi vesicle-mediated transport [IBA]
- protein targeting to vacuole [IBA]
- retrograde transport, endosome to Golgi [IDA, IMP]
- vesicle fusion with Golgi apparatus [IBA, ISS]
- voluntary musculoskeletal movement [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER to Golgi transport vesicle membrane [IBA]
- Golgi apparatus [IDA]
- SNARE complex [IBA, ISS, TAS]
- clathrin-coated vesicle [ISS]
- endoplasmic reticulum membrane [IBA]
- endosome [ISS]
- late endosome membrane [IBA]
- neuron projection terminus [ISS]
- neuronal cell body [ISS]
- perinuclear region of cytoplasm [ISS]
- synaptic vesicle [ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform.
The molecular mechanisms underlying early/recycling endosomes-to-TGN transport are still not understood. We identified interactions between the TGN-localized putative t-SNAREs syntaxin 6, syntaxin 16, and Vti1a, and two early/recycling endosomal v-SNAREs, VAMP3/cellubrevin, and VAMP4. Using a novel permeabilized cell system, these proteins were functionally implicated in the post-Golgi retrograde transport step. The function of Rab6a' was also required, whereas its closely ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
VTI1A VAMP3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 3375128 |
Curated By
- BioGRID