GAB2
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- innate immune response [TAS]
- osteoclast differentiation [IMP]
- phosphatidylinositol-mediated signaling [ISS]
- positive regulation of cell proliferation [IDA]
- positive regulation of mast cell degranulation [ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA]
Gene Ontology Molecular Function
ZAP70
Gene Ontology Biological Process
- B cell activation [TAS]
- T cell activation [TAS]
- T cell aggregation [TAS]
- T cell differentiation [NAS]
- T cell migration [TAS]
- T cell receptor signaling pathway [IBA, TAS]
- adaptive immune response [TAS]
- cell migration [IBA]
- immune response [IDA]
- innate immune response [IBA]
- intracellular signal transduction [NAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IMP]
- positive regulation of T cell differentiation [IDA]
- positive regulation of alpha-beta T cell proliferation [IBA]
- positive thymic T cell selection [IDA]
- protein phosphorylation [IDA, NAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules.
To maintain various T cell responses and immune equilibrium, activation signals triggered by T cell antigen receptor (TCR) must be regulated by inhibitory signals. Gab2, an adaptor protein of the insulin receptor substrate-1 family, has been shown to be involved in the downstream signaling from cytokine receptors. We investigated the functional role of Gab2 in TCR-mediated signal transduction. Gab2 was ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID