BAIT

SEMA4C

M-SEMA-F, SEMACL1, SEMAF, SEMAI, UNQ5855/PRO34487
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
Homo sapiens
PREY

DLG2

PPP1R58, PSD-93, PSD93, chapsyn-110
discs, large homolog 2 (Drosophila)
GO Process (2)
GO Function (2)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95.

Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, Kurinami H, Miyazaki N, Tohyama M, Furuyama T

Semaphorins are known to act as chemorepulsive molecules that guide axons during neural development. Sema4C, a group 4 semaphorin, is a transmembrane semaphorin of unknown function. The cytoplasmic domain of Sema4C contains a proline-rich region that may interact with some signaling proteins. In this study, we demonstrate that Sema4C is enriched in the adult mouse brain and associated with PSD-95 ... [more]

J. Biol. Chem. Mar. 23, 2001; 276(12);9174-81 [Pubmed: 11134026]

Throughput

  • Low Throughput

Curated By

  • BioGRID