NHR-49
Gene Ontology Biological Process
- determination of adult lifespan [IMP]
- embryo development ending in birth or egg hatching [IMP]
- lipid storage [IMP]
- locomotion [IMP]
- nematode larval development [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- receptor-mediated endocytosis [IMP]
- regulation of fatty acid metabolic process [IMP]
- regulation of lipid metabolic process [IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
NHR-256
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Coordinate regulation of lipid metabolism by novel nuclear receptor partnerships.
Mammalian nuclear receptors broadly influence metabolic fitness and serve as popular targets for developing drugs to treat cardiovascular disease, obesity, and diabetes. However, the molecular mechanisms and regulatory pathways that govern lipid metabolism remain poorly understood. We previously found that the Caenorhabditis elegans nuclear hormone receptor NHR-49 regulates multiple genes in the fatty acid beta-oxidation and desaturation pathways. Here, we ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NHR-49 NHR-256 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - | |
| NHR-49 NHR-256 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |