BAIT
MAP3K10
MEKK10, MLK2, MST
mitogen-activated protein kinase kinase kinase 10
GO Process (13)
GO Function (6)
GO Component (1)
Gene Ontology Biological Process
- JNK cascade [TAS]
- activation of JNKK activity [ISS]
- activation of JUN kinase activity [ISS]
- apoptotic process [TAS]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- negative regulation of transcription, DNA-templated [IMP, ISS]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of JNK cascade [IMP]
- positive regulation of JUN kinase activity [IMP]
- protein autophosphorylation [ISS]
- signal transduction [TAS]
- smoothened signaling pathway [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
DNM1
DNM
dynamin 1
GO Process (4)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mixed-lineage kinase 2-SH3 domain binds dynamin and greatly enhances activation of GTPase by phospholipid.
Mixed-lineage kinase 2 (MLK2) is a cytoplasmic protein kinase expressed at high levels in mammalian brain. The MLK2 structure is composed of a Src homology 3 (SH3) domain, two leucine zippers, a basic motif, a Cdc42/Rac interactive binding motif and a large C-terminal domain rich in proline, serine and threonine residues. To begin to define the role of MLK2 in ... [more]
Biochem. J. Oct. 01, 1998; 335(0);119-24 [Pubmed: 9742220]
Throughput
- Low Throughput
Curated By
- BioGRID