BAIT
L1CAM
CAML1, CD171, HSAS, HSAS1, MASA, MIC5, N-CAM-L1, N-CAML1, NCAM-L1, S10, SPG1
L1 cell adhesion molecule
GO Process (6)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
NCAN
CSPG3
neurocan
GO Process (12)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- axon guidance [TAS]
- carbohydrate metabolic process [TAS]
- cell adhesion [IBA]
- central nervous system development [IBA]
- chondroitin sulfate biosynthetic process [TAS]
- chondroitin sulfate catabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- dermatan sulfate biosynthetic process [TAS]
- extracellular matrix organization [TAS]
- glycosaminoglycan metabolic process [TAS]
- skeletal system development [IBA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth.
We have previously shown that aggregation of microbeads coated with N-CAM and Ng-CAM is inhibited by incubation with soluble neurocan, a chondroitin sulfate proteoglycan of brain, suggesting that neurocan binds to these cell adhesion molecules (Grumet, M., A. Flaccus, and R. U. Margolis. 1993. J. Cell Biol. 120:815). To investigate these interactions more directly, we have tested binding of soluble ... [more]
J. Cell Biol. May. 01, 1994; 125(3);669-80 [Pubmed: 7513709]
Throughput
- Low Throughput
Curated By
- BioGRID