CELE_F08C6.7, F08C6.7

unc-98 encodes a protein with four C2H2 zinc fingers and several possible nuclear localization and export sequences; UNC-98 is required for normal mobility, M-line, and dense body (Z-disk analog) structures; UNC-98 binds the C-terminal portion of myosin heavy chain, as well as a number of proteins that localize to the base of dense bodies and M lines, including UNC-97/PINCH, suggesting that in vivo UNC-98 functions to link myosin thick filaments to an integrin-associated protein complex at the muscle cell membrane; UNC-98 also interacts with UNC-96, UNC-15/paramyosin, the unconventional myosin HUM-6 and the zinc-finger protein MEP-1; UNC-98 localizes to M-lines, muscle cell nuclei, and perhaps also to dense bodies.

CELE_B0547.1, B0547.1

csn-5 encodes an ortholog of subunit 5 of the COP9 signalosome complex (CSN5), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; CSN-5 (along with KGB-1 and ZYX-1) physically binds germline RNA helicases (GLH proteins), and csn-5(RNAi) results in sterile worms with small gonads and no oocytes, causing oogenesis to cease, but not affecting the initial assembly of P granules -- a defect essentially identical to that produced by RNAi with a combination of glh-1 and glh-4.