BAIT

FLP-18

CELE_Y48D7A.2, Y48D7A.2

flp-18 encodes the only FMRFamide-related neuropeptide (FaRP) encoded by the C. elegans genome, other than flp-21, that activates the solitary (215V) form of NPR-1 in Xenopus oocytes; in addition, FLP-18 can activated the social (215F) form of NPR-1 in pharyngeal assays; FLP-18 is expressed in the interneurons AVA, AIY and RIG, the motor neuron RIM and the pharyngeal neurons M2 and M3.

GO Process (2)

GO Function (0)

GO Component (1)

Gene Ontology Biological Process

embryo development ending in birth or egg hatching [IMP]

neuropeptide signaling pathway [IDA]

Gene Ontology Cellular Component

extracellular region [IC]

WormBase Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Caenorhabditis elegans

PREY

NPR-4

CELE_C16D6.2

Protein NPR-4

GO Process (0)

GO Function (0)

GO Component (0)

WormBase Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Caenorhabditis elegans

Biochemical Activity

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Pharmacological and functional similarities of the human neuropeptide Y system in C. elegans challenges phylogenetic views on the FLP/NPR system.

Gershkovich MM, Gross VE, Kaiser A, Proemel S

The neuropeptide Y system affects various processes, among others food intake, and is frequently discussed in the context of targeting obesity. Studies in model organisms are indispensable to enable molecular studies in a physiological context. Although the NPY system is evolutionarily conserved in all bilaterians, in the widely used model Caenorhabditis elegans there is controversy on the existence of NPY ... [more]

Cell Commun Signal Dec. 18, 2018; 17(1);123 [Pubmed: 31533726]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
FLP-18 NPR-4	Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.	Cohen M (2009)	Low	-	WormBase	2838079
NPR-4 FLP-18	Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.	Beets I (2023)	High	-	BioGRID	3711952

Curated By

WormBase

Interaction Summary