BAIT
BRD1
BRL, BRPF1, BRPF2, RP3-522J7.4
bromodomain containing 1
GO Process (1)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SCRIB
CRIB1, SCRB1, SCRIB1, Vartul
scribbled planar cell polarity protein
GO Process (13)
GO Function (1)
GO Component (9)
Gene Ontology Biological Process
- activation of Rac GTPase activity [IMP]
- apoptotic process involved in morphogenesis [IMP]
- cell migration [IMP]
- cell proliferation [IDA]
- establishment of apical/basal cell polarity [IMP]
- mammary gland duct morphogenesis [ISS]
- negative regulation of mitotic cell cycle [IDA]
- neural tube closure [IMP]
- positive chemotaxis [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of receptor recycling [IMP]
- protein localization to adherens junction [IMP]
- single organismal cell-cell adhesion [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.
Bromodomain proteins (BRD) are key chromatin regulators of genome function and stability as well as therapeutic targets in cancer. Here, we systematically delineate the contribution of human BRD proteins for genome stability and DNA double-strand break (DSB) repair using several cell-based assays and proteomic interaction network analysis. Applying these approaches, we identify 24 of the 42 BRD proteins as promoters ... [more]
Genes Dev Dec. 01, 2018; 33(23-24);1751-1774 [Pubmed: 31753913]
Throughput
- High Throughput
Curated By
- BioGRID