BAIT
ARP4
ACT3, L000000027, YJL081C
Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes
GO Process (7)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
SNF5
HAF4, SWI10, TYE4, L000001948, YBR289W
Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions
GO Process (6)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- carbon catabolite activation of transcription from RNA polymerase II promoter [IGI]
- chromatin remodeling [IGI, IMP]
- double-strand break repair via homologous recombination [IMP]
- positive regulation of invasive growth in response to glucose limitation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- sucrose catabolic process [IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation.
Histone acetylation and deacetylation are among the principal mechanisms by which chromatin is regulated during transcription, DNA silencing, and DNA repair. We analyzed patterns of genetic interactions uncovered during comprehensive genome-wide analyses in yeast to probe how histone acetyltransferase (HAT) and histone deacetylase (HDAC) protein complexes interact. The genetic interaction data unveil an underappreciated role of HDACs in maintaining cellular ... [more]
Genes Dev. Aug. 01, 2008; 22(15);2062-74 [Pubmed: 18676811]
Throughput
- High Throughput|Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- High Throughput: dSLAM analysis was performed to determine genome-wide genetic interaction profiles of 38 query genes involved in histone (de)acetylation.
- Low Throughput: Genetic interactions identified using dSLAM were validated by tetrad dissection and/or random spore analysis.
Curated By
- BioGRID