BRD3
Gene Ontology Biological Process
Gene Ontology Molecular Function
SRPK2
Gene Ontology Biological Process
- RNA splicing [IDA]
- angiogenesis [ISS]
- innate immune response [IC]
- intracellular signal transduction [IDA]
- negative regulation of viral genome replication [IDA]
- nuclear speck organization [ISS]
- positive regulation of cell cycle [ISS]
- positive regulation of cell proliferation [IDA]
- positive regulation of gene expression [ISS]
- positive regulation of neuron apoptotic process [ISS]
- positive regulation of viral genome replication [IDA]
- protein phosphorylation [IDA]
- regulation of mRNA splicing, via spliceosome [TAS]
- spliceosomal complex assembly [IDA]
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.
Bromodomain proteins (BRD) are key chromatin regulators of genome function and stability as well as therapeutic targets in cancer. Here, we systematically delineate the contribution of human BRD proteins for genome stability and DNA double-strand break (DSB) repair using several cell-based assays and proteomic interaction network analysis. Applying these approaches, we identify 24 of the 42 BRD proteins as promoters ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SRPK2 BRD3 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | High | - | BioGRID | 907247 |
Curated By
- BioGRID