BAIT
ZMYND8
PRKCBP1, PRO2893, RACK7, RP5-890O15.1
zinc finger, MYND-type containing 8
GO Process (1)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
WWC1
HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168
WW and C2 domain containing 1
GO Process (9)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- cell migration [IDA]
- establishment of cell polarity [TAS]
- hippo signaling [TAS]
- negative regulation of hippo signaling [IDA]
- negative regulation of organ growth [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of MAPK cascade [IDA]
- regulation of hippo signaling [IMP]
- regulation of intracellular transport [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.
Bromodomain proteins (BRD) are key chromatin regulators of genome function and stability as well as therapeutic targets in cancer. Here, we systematically delineate the contribution of human BRD proteins for genome stability and DNA double-strand break (DSB) repair using several cell-based assays and proteomic interaction network analysis. Applying these approaches, we identify 24 of the 42 BRD proteins as promoters ... [more]
Genes Dev Dec. 01, 2018; 33(23-24);1751-1774 [Pubmed: 31753913]
Throughput
- High Throughput
Curated By
- BioGRID