BAIT
AR
AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM, RP11-383C12.1
androgen receptor
GO Process (23)
GO Function (16)
GO Component (5)
Gene Ontology Biological Process
- androgen receptor signaling pathway [IDA]
- cell growth [NAS]
- cell proliferation [NAS]
- cell-cell signaling [TAS]
- gene expression [TAS]
- intracellular receptor signaling pathway [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IDA]
- negative regulation of integrin biosynthetic process [IDA]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of cell proliferation [IDA]
- positive regulation of integrin biosynthetic process [IDA]
- positive regulation of phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase III promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- prostate gland development [NAS]
- protein oligomerization [IDA]
- regulation of establishment of protein localization to plasma membrane [IDA]
- sex differentiation [NAS]
- signal transduction [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [IDA]
- transport [TAS]
Gene Ontology Molecular Function- DNA binding [NAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription factor binding [IPI]
- androgen binding [NAS]
- androgen receptor activity [IDA, IMP, NAS, TAS]
- beta-catenin binding [IDA, IPI, TAS]
- chromatin binding [IDA]
- enzyme binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [NAS]
- receptor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [NAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription factor binding [IPI]
- androgen binding [NAS]
- androgen receptor activity [IDA, IMP, NAS, TAS]
- beta-catenin binding [IDA, IPI, TAS]
- chromatin binding [IDA]
- enzyme binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [NAS]
- receptor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
CRK
CRKII, p38
v-crk avian sarcoma virus CT10 oncogene homolog
GO Process (11)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- activation of MAPKK activity [TAS]
- blood coagulation [TAS]
- ephrin receptor signaling pathway [IDA]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- regulation of Rho GTPase activity [IDA]
- regulation of actin cytoskeleton organization [IDA]
- regulation of transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.
Many human diseases are associated with aberrant regulation of phosphoprotein signaling networks. Src homology 2 (SH2) domains represent the major class of protein domains in metazoans that interact with proteins phosphorylated on the amino acid residue tyrosine. Although current SH2 domain prediction algorithms perform well at predicting the sequences of phosphorylated peptides that are likely to result in the highest ... [more]
Mol. Cell Proteomics Jul. 01, 2014; 13(7);1705-23 [Pubmed: 24728074]
Quantitative Score
- 9.14 [KD]
Throughput
- High Throughput
Additional Notes
- interaction assayed using fluorescence polarization (FP) measurements using one or more phosphopeptides derived from the bait protein and all or a portion of the purified prey protein
- this results in one or more KD values measured in micromolar (9.14) of which the minimum value representing the highest affinity interaction is reported in the HTP score
Curated By
- BioGRID