KIT
Gene Ontology Biological Process
- Fc receptor signaling pathway [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- Kit signaling pathway [IDA]
- T cell differentiation [ISS]
- actin cytoskeleton reorganization [IDA]
- activation of MAPK activity [IDA]
- cell chemotaxis [IDA]
- cytokine-mediated signaling pathway [IDA]
- dendritic cell cytokine production [ISS]
- detection of mechanical stimulus involved in sensory perception of sound [ISS]
- digestive tract development [ISS]
- embryonic hemopoiesis [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- erythrocyte differentiation [ISS]
- erythropoietin-mediated signaling pathway [ISS]
- fibroblast growth factor receptor signaling pathway [TAS]
- hemopoiesis [TAS]
- immature B cell differentiation [ISS]
- inflammatory response [ISS]
- innate immune response [TAS]
- lamellipodium assembly [ISS]
- male gonad development [IEP]
- mast cell chemotaxis [IDA]
- mast cell cytokine production [IDA]
- mast cell degranulation [IMP]
- mast cell differentiation [ISS, TAS]
- mast cell proliferation [TAS]
- megakaryocyte development [ISS]
- melanocyte adhesion [ISS]
- melanocyte differentiation [ISS, TAS]
- melanocyte migration [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- ovarian follicle development [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- pigmentation [ISS]
- positive regulation of JAK-STAT cascade [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [TAS]
- positive regulation of phosphatidylinositol 3-kinase signaling [TAS]
- positive regulation of phospholipase C activity [TAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of tyrosine phosphorylation of Stat1 protein [IMP]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IMP]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IMP]
- protein autophosphorylation [IDA]
- regulation of cell proliferation [TAS]
- regulation of cell shape [ISS]
- signal transduction [TAS]
- signal transduction by phosphorylation [TAS]
- spermatogenesis [ISS, TAS]
- stem cell differentiation [ISS]
- stem cell maintenance [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SHC1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [IDA]
- Ras protein signal transduction [TAS]
- activation of MAPK activity [IDA]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- blood coagulation [TAS]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum unfolded protein response [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [IBA, ISS, TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [TAS]
- platelet activation [TAS]
- positive regulation of DNA replication [ISS]
- positive regulation of cell proliferation [NAS]
- regulation of epidermal growth factor-activated receptor activity [TAS]
Gene Ontology Molecular Function- ephrin receptor binding [IPI]
- epidermal growth factor receptor binding [ISS]
- insulin receptor binding [IPI]
- insulin-like growth factor receptor binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- phospholipid binding [TAS]
- protein binding [IPI]
- protein kinase binding [IBA]
- protein tyrosine kinase activity [TAS]
- transmembrane receptor protein tyrosine kinase adaptor activity [TAS]
- ephrin receptor binding [IPI]
- epidermal growth factor receptor binding [ISS]
- insulin receptor binding [IPI]
- insulin-like growth factor receptor binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- phospholipid binding [TAS]
- protein binding [IPI]
- protein kinase binding [IBA]
- protein tyrosine kinase activity [TAS]
- transmembrane receptor protein tyrosine kinase adaptor activity [TAS]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.
Many human diseases are associated with aberrant regulation of phosphoprotein signaling networks. Src homology 2 (SH2) domains represent the major class of protein domains in metazoans that interact with proteins phosphorylated on the amino acid residue tyrosine. Although current SH2 domain prediction algorithms perform well at predicting the sequences of phosphorylated peptides that are likely to result in the highest ... [more]
Quantitative Score
- 0.37 [KD]
Throughput
- High Throughput
Additional Notes
- interaction assayed using fluorescence polarization (FP) measurements using one or more phosphopeptides derived from the bait protein and all or a portion of the purified prey protein
- this results in one or more KD values measured in micromolar (0.37,0.41,1.73,4.63,6.94,11.03,12.98,14.37) of which the minimum value representing the highest affinity interaction is reported in the HTP score
Curated By
- BioGRID