BAIT
PRNP
ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30, RP5-1068H6.2
prion protein
GO Process (12)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- axon guidance [TAS]
- cellular copper ion homeostasis [NAS]
- metabolic process [TAS]
- negative regulation of T cell receptor signaling pathway [ISS]
- negative regulation of activated T cell proliferation [ISS]
- negative regulation of calcineurin-NFAT signaling cascade [ISS]
- negative regulation of interferon-gamma production [ISS]
- negative regulation of interleukin-17 production [ISS]
- negative regulation of interleukin-2 production [ISS]
- negative regulation of protein phosphorylation [ISS]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISS]
- response to oxidative stress [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DLG1
DLGH1, SAP-97, SAP97, dJ1061C18.1.1, hdlg
discs, large homolog 1 (Drosophila)
GO Process (17)
GO Function (11)
GO Component (17)
Gene Ontology Biological Process
- actin filament organization [IDA]
- axon guidance [TAS]
- cortical actin cytoskeleton organization [IDA]
- dephosphorylation [TAS]
- endothelial cell proliferation [IDA]
- establishment or maintenance of cell polarity [TAS]
- mitotic cell cycle checkpoint [NAS]
- negative regulation of mitotic cell cycle [IMP]
- nucleotide phosphorylation [TAS]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- positive regulation of potassium ion transport [IDA]
- protein localization to plasma membrane [IMP, TAS]
- regulation of membrane potential [IDA]
- regulation of sodium ion transmembrane transport [TAS]
- single organismal cell-cell adhesion [IDA]
- synaptic transmission [TAS]
- tight junction assembly [IDA]
Gene Ontology Molecular Function- L27 domain binding [IPI]
- cytoskeletal protein binding [TAS]
- guanylate kinase activity [TAS]
- ion channel binding [IPI]
- mitogen-activated protein kinase kinase binding [IPI]
- phosphatase binding [IPI]
- phosphoprotein phosphatase activity [TAS]
- potassium channel regulator activity [IDA, NAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- L27 domain binding [IPI]
- cytoskeletal protein binding [TAS]
- guanylate kinase activity [TAS]
- ion channel binding [IPI]
- mitogen-activated protein kinase kinase binding [IPI]
- phosphatase binding [IPI]
- phosphoprotein phosphatase activity [TAS]
- potassium channel regulator activity [IDA, NAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- MPP7-DLG1-LIN7 complex [IDA]
- basolateral plasma membrane [IDA]
- cell junction [IDA]
- cell-cell junction [IDA]
- cytoplasm [IDA]
- cytoplasmic side of plasma membrane [IDA]
- cytosol [TAS]
- endoplasmic reticulum [IDA]
- extracellular vesicular exosome [IDA]
- immunological synapse [TAS]
- intercalated disc [TAS]
- microtubule [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [TAS]
- tight junction [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.
The cellular prion protein (PrPC) is implicated in neuroprotective signaling and neurotoxic pathways in both prion diseases and Alzheimer's disease (AD). Specifically, the intrinsically disordered N-terminal domain (N-PrP) has been shown to interact with neurotoxic ligands, such as A? and Scrapie prion protein (PrPSc), and to be crucial for the neuroprotective activity of PrPC. To gain further insight into cellular ... [more]
PLoS One May. 24, 2018; 13(5);e0197659 [Pubmed: 29791485]
Throughput
- High Throughput
Additional Notes
- interaction identified using tandem mass spectrometry in Alzheimer's disease (AD) brain tissue but not in non-AD brain tissue
Curated By
- BioGRID