BAIT
AIM2
PYHIN4, RP11-520H16.3
absent in melanoma 2
GO Process (15)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- activation of innate immune response [IDA]
- cellular response to drug [IDA]
- immune response [TAS]
- innate immune response [TAS]
- interleukin-1 beta secretion [IMP]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of cysteine-type endopeptidase activity [IDA]
- positive regulation of defense response to virus by host [ISS]
- positive regulation of interleukin-1 beta production [IDA]
- positive regulation of interleukin-1 beta secretion [IDA]
- positive regulation of protein oligomerization [IDA]
- pyroptosis [IDA]
- tumor necrosis factor-mediated signaling pathway [IDA]
Gene Ontology Molecular Function
Homo sapiens
PREY
CAMK2D
CAMKD
calcium/calmodulin-dependent protein kinase II delta
GO Process (32)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- cardiac muscle cell contraction [ISS]
- cellular response to calcium ion [TAS]
- cytokine-mediated signaling pathway [TAS]
- endoplasmic reticulum calcium ion homeostasis [ISS]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of sodium ion transmembrane transport [IDA]
- negative regulation of sodium ion transmembrane transporter activity [IDA]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of cardiac muscle hypertrophy [IMP]
- protein autophosphorylation [IDA]
- protein oligomerization [IDA]
- protein phosphorylation [IDA]
- regulation of cardiac muscle cell action potential [ISS]
- regulation of cardiac muscle cell action potential involved in regulation of contraction [IC]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IC, TAS]
- regulation of cell communication by electrical coupling [ISS]
- regulation of cell communication by electrical coupling involved in cardiac conduction [IC]
- regulation of cell growth [NAS]
- regulation of cellular localization [IMP]
- regulation of generation of L-type calcium current [ISS]
- regulation of heart contraction [TAS]
- regulation of heart rate by cardiac conduction [IC]
- regulation of histone deacetylase activity [TAS]
- regulation of membrane depolarization [IDA]
- regulation of relaxation of cardiac muscle [IDA]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISS]
- regulation of ryanodine-sensitive calcium-release channel activity [TAS]
- regulation of the force of heart contraction [TAS]
- regulation of transcription from RNA polymerase II promoter [TAS]
- relaxation of cardiac muscle [ISS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.
The human PYHIN proteins, AIM2, IFI16, IFIX, and MNDA, are critical regulators of immune response, transcription, apoptosis, and cell cycle. However, their protein interactions and underlying mechanisms remain largely uncharacterized. Here, we provide the interaction network for all PYHIN proteins and define a function in sensing of viral DNA for the previously uncharacterized IFIX protein. By designing a cell-based inducible ... [more]
Unknown Feb. 09, 2015; 11(1);787 [Pubmed: 25665578]
Quantitative Score
- 0.71165 [Saint Score]
Throughput
- High Throughput
Additional Notes
- note, however, that inclusion of interactors in the article was dependent on more complex criteria than that single averaged SAINT score
- the indicated score for the interactor/prey protein is the average of SAINT scores for that interactor from affinity purification experiments using both N- and C-terminally tagged constructs of the indicated bait protein
Curated By
- BioGRID