PYHIN1
GPC4
Gene Ontology Biological Process
- anatomical structure morphogenesis [TAS]
- carbohydrate metabolic process [TAS]
- cell proliferation [TAS]
- chondroitin sulfate metabolic process [TAS]
- glycosaminoglycan biosynthetic process [TAS]
- glycosaminoglycan catabolic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- phototransduction, visible light [TAS]
- retinoid metabolic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.
The human PYHIN proteins, AIM2, IFI16, IFIX, and MNDA, are critical regulators of immune response, transcription, apoptosis, and cell cycle. However, their protein interactions and underlying mechanisms remain largely uncharacterized. Here, we provide the interaction network for all PYHIN proteins and define a function in sensing of viral DNA for the previously uncharacterized IFIX protein. By designing a cell-based inducible ... [more]
Quantitative Score
- 0.8725 [Saint Score]
Throughput
- High Throughput
Additional Notes
- note, however, that inclusion of interactors in the article was dependent on more complex criteria than that single averaged SAINT score
- the indicated score for the interactor/prey protein is the average of SAINT scores for that interactor from affinity purification experiments using both N- and C-terminally tagged constructs of the indicated bait protein
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PYHIN1 GPC4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID